Camera 2019 - Tfeb, Jem | the journal of experimental medicine, Salou et al. wondered what could differentiate mait and nkt cells, if not for tcr specificity. once split according to rorγt and t-bet–expressing subsets, mait and nkt share almost identical transcriptional programs acquired in the thymus, which result in specific tissue residency patterns.. Autophagy inhibits the accumulation of advanced - diabetes, Advanced glycation end products (ages) are involved in the progression of diabetic nephropathy. ages filtered by glomeruli or delivered from the circulation are endocytosed and degraded in the lysosomes of kidney proximal tubular epithelial cells (ptecs). autophagy is a highly conserved degradation system that regulates intracellular homeostasis by engulfing cytoplasmic components.. Akt/pkb signaling pathway - wikipedia, The akt pathway, or pi3k-akt pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. key proteins involved are pi3k (phosphatidylinositol 3-kinase) and akt (protein kinase b) initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of pi3k. . activated pi3k then phosphorylates ..